JMJD1A Antibody

Blue Ice

Predicted: 147kD
Observed: 147kD

JMJD1A Antibody: The jumonji domain containing 1A protein (JMJD1A) was originally discovered as a testes specific gene, but has been found to be expressed in numerous tissues. JMJD1A is a histone demethylase and specifically demethylates mono- and dimethyl-H3K9. It has also been found to be a novel interaction partner with ER71, a transcription factor expressed in the testes of adult mice and during embryogenesis. JMJD1A is also a downstream gene of STAT3, a protein that has been found to be important in the maintenance of mouse embryonic stem (mES) cells, and decreased JMJD1A expression correlated with the differentiation of cultured mES cells following the removal of the cytokine LIF. These findings suggest that JMJD1A might be a critical signaling molecule underlying the maintenance of pluripotency in embryonic stem cells. At least two isoforms of JMJD1A are known to exist.

Trial Size

20357522

Human JMJD1A has one isoform (1321aa, 147kD). Mouse JMJD1A has 2 isoforms, including isoform 1 (1323aa, 148kD) and isoform 2 (831aa, 94kD). Rat JMJD1A has one isoform (1323aa, 148kD). 5365 can detect human, mouse and rat.

Cat. No. 1211 - HepG2 Cell Lysate

PRS-1219-0.1mg

JMJD1A Antibody is supplied in PBS containing 0.02% sodium azide.

Predicted species reactivity based on immunogen sequence: Mouse: (94%), Chicken: (87%)

Anti-JMJD1A antibody (5365) was raised against a peptide corresponding to 16 amino acids near the amino terminus of human JMJD1A.

The immunogen is located within amino acids 50-100 of JMJD1A.

lysine (K)-specific demethylase 3A

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.