WRN Antibody

Rabbit Ig

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

This gene encodes a member of the RecQ subfamily and the
DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA
helicases are involved in many aspects of DNA metabolism, including
transcription, replication, recombination, and repair. This protein
contains a nuclear localization signal in the C-terminus and shows
a predominant nucleolar localization. It possesses an intrinsic 3'
to 5' DNA helicase activity, and is also a 3' to 5' exonuclease.
Based on interactions between this protein and Ku70/80 heterodimer
in DNA end processing, this protein may be involved in the repair
of double strand DNA breaks. Defects in this gene are the cause of
Werner syndrome, an autosomal recessive disorder characterized by
premature aging.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This WRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 787-816 amino acids from the Central region of human WRN.

Werner syndrome ATP-dependent helicase

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.