WRN Antibody

Rabbit Ig

Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

This gene encodes a member of the RecQ subfamily and theDEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNAhelicases are involved in many aspects of DNA metabolism, includingtranscription, replication, recombination, and repair. This proteincontains a nuclear localization signal in the C-terminus and showsa predominant nucleolar localization. It possesses an intrinsic 3'to 5' DNA helicase activity, and is also a 3' to 5' exonuclease.Based on interactions between this protein and Ku70/80 heterodimerin DNA end processing, this protein may be involved in the repairof double strand DNA breaks. Defects in this gene are the cause ofWerner syndrome, an autosomal recessive disorder characterized bypremature aging.

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

Polyclonal

Homo sapiens