SIRT4 Antibody

ArtNr	PRS-5769-0.1mg
Hersteller	ProSci
Menge	0.1 mg
Quantity options	0.02 mg 0.1 mg
Kategorie	Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Antibodies Western Blot ELISA Primary Antibodies
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Chicken
Isotype	IgY
Konjugat/Tag	Unconjugated
Citations	Salminen A. SIRT1: regulation of longevity via autophagy. Cell Signal2009; 21:1356-60. Afshar G and Murnane JP. Characterization of a human gene with sequence homology to Saccharomyces cerevisiae Sir 2. Gene1999; 234:161-8. Guarente L. Sirtuins as potential targets for metabolic syndrome. Nature2006; 444:868-74. Vaziri H, Dessain SK, Ng Eaton E, et al. hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase. Cell2001; 107:149-59.
NCBI	SIRT4
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	SIRT4 Antibody: SIR2L4, SIR2L4, NAD-dependent protein deacetylase sirtuin-4, NAD-dependent ADP-ribosyltransferase sirtuin-4
Lieferbar
Manufacturer - Applications	SIRT4 antibody can be used for detection of SIRT4 by Western blot at 1 - 2 μg/mL. Antibody validated: Western Blot in human and mouse samples. All other applications and species not yet tested.
Shipping Temperature	blue ice or room temperature
Storage Conditions	SIRT4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight	Predicted: 37 kDa Observed: 40 kDa
Manufacturer - Research Area	Homeostasis
Background	SIRT4 Antibody: The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence and lifespan extension. Sirtuins, including SIRT1-7, are human homologs of yeast Sir2p. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) which regulate cellular metabolism, e.g. energy metabolism, and thereby are associated with aging and several age-related diseases. SIRT4 localizes to mitochondria, inhibits glutamate dehydrogenase, and is thought to be involved in the regulation of insulin secretion.
Protein Gi #	119618588
Purification	SIRT4 Antibody is affinity chromatography purified via peptide column.
Positive Control 1	PRS-1304-0.1mg
Positive Control 2	PRS-1404-0.1mg
Concentration	1 mg/ml
Buffer	SIRT4 Antibody is supplied in PBS containing 0.02% sodium azide.
Homology	Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen	SIRT4 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human SIRT4. The immunogen is located within amino acids 80 - 130 of SIRT4.
Clonality	Polyclonal
NCBI Official Name	sirtuin 4
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 0.1 mg

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