KLOTHO Antibody

Blue Ice

Predicted: 116kD
Observed: 116kD

KLOTHO Antibody: KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.

Trial Size

24497614

Human KLOTHO has 2 isoforms, including isoform 1 (1012aa, 116kD) and isoform 2 (549aa, 62kD). Mouse KLOTHO has 2 isoforms, including isoform 1 (1014aa, 116kD) and isoform 2 (550aa, 62kD). Rat KLOTHO has one isoform (1014aa, 117kD). 6107 can detect human, mouse and rat.

PRS-1203-0.1mg

PRS-1205-0.1mg

1 mg/mL

WB: 1-4 μ g/mL; IHC: 2.5 μ g/mL; IF: 20 μ g/mL.
Antibody validated: Western Blot in human, mouse and rat samples; Immunohistochemistry in mouse and rat samples; Immunofluorescence in mouse samples. All other applications and species not yet tested.

Anti-KLOTHO antibody (6107) was raised against a peptide corresponding to 17 amino acids near the center of human KLOTHO.

The immunogen is located within amino acids 410-460 of KLOTHO.

klotho

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.