DYRK1A Antibody

ArtNr	PRS-6255-0.02mg
Hersteller	ProSci
Menge	0.02 mg
Quantity options	0.02 mg 0.1 mg
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Antibodies Western Blot ELISA Immunocytochemistry Primary Antibodies By Organ Lung Cancer Bladder Cancer Breast Cancer
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, ICC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	Park J, Oh Y, and Chung KC. Two key genes closely implicated with the neuropathological characteristics in Down Syndrome: DYRK1A and RCAN1. BMB Reports 2009; 42:6-15. Park J, Oh Y, You L, et al. Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. J. Biol. Chem. 2010; 285:31895-906 Li D, Jackson RA, Yusoff P, et al. Direct association of Sprouty-related protein with and EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions. J. Biol. Chem. 2010; 285:35374-85.
NCBI	DYRK1A
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	DYRK1A Antibody: MNB,DYRK,HP86,MNBH,MRD7,DYRK1,MNB,Dual specificity tyrosine-phosphorylation-regulated kinase 1A,Dual specificity YAK1-related kinase
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Primary Antibodies
Shipping Temperature	Blue Ice
Storage Conditions	DYRK1A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight	Predicted: 84 kDa Observed: 90 kDa
Manufacturer - Research Area	Neuroscience
Background	DYRK1A Antibody: DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family and is thought to be involved in neuronal differentiation, neurodegenerative diseases, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. DYRK1A phosphorylates several transcription factors such as p53, leading to inhibition of embryonic neuronal cell proliferation. DYRK1A associates with multiple proteins, including SPRED1 and SPRED2; this association appears to inhibit the phosphorylation activity of DYRK1A. Recent evidence also suggests that DYRK1A may be involved in the replication of HIV-1.
By Type	Neuroscience
Badges	Trial Size
Modifications	None
Protein Gi #	18765758
Purification	DYRK1A Antibody is affinity chromatography purified via peptide column.
Positive Control 1	PRS-1201-0.1mg
Positive Control 2	PRS-17-001-1pack
Positive Control 3	PRS-1204-0.1mg
Concentration	1 mg/mL
Buffer	DYRK1A Antibody is supplied in PBS containing 0.02% sodium azide.
Application Note	DYRK1A antibody can be used for detection of DYRK1A by Western blot at 1 - 2 μ g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ g/mL. Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.
Manufacturer - Specificity	Multiple isoforms of DYRK1A are known to exist. DYRK1A antibody will not cross-react with other DYRK family members
Immunogen	DYRK1A antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human DYRK1A. The immunogen is located within the last 50 amino acids of DYRK1A.
Clonality	Polyclonal
NCBI Official Name	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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