EI24 Antibody

Primary Antibodies

EI24 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

EI24 Antibody: The etoposide-induced 24 (EI24) protein is an immediate-early induction target of p53-mediated apoptosis and functions as a tumor suppressor. EI24 contains six transmembrane domains and is localized to the endoplasmic reticulum (ER). It binds to Bcl-2 and may contribute to apoptosis by modulating the activity and function of Bcl-2. EI24 is highly mutated in aggressive breast cancers and its loss in breast cancer tissue correlates with tumor invasiveness. Similar findings in invasive cervical carcinoma suggest that EI24 may be a promising therapeutic target in the treatment of invasive cancer.

Trial Size

55956766

PRS-1464-0.1mg

EI24 Antibody is supplied in PBS containing 0.02% sodium azide.

Predicted species reactivity based on immunogen sequence: Bovine: (95%)

EI24 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human EI24.

The immunogen is located within the last 50 amino acids of EI24.

etoposide induced 2.4 mRNA

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.