JMJD3 Antibody

Blue Ice

Predicted: 180
Observed: 180 kD

JMJD3 Antibody: The Jumonji domain-containing protein 3 (JMJD3) functions as a trimethylation-specific demethylase, converting the trimethylated histone H3 Lys27 residue to the dimethylated form, and is thought to also function as a transcriptional repressor. JMJD3 plays a central role in regulation of posterior development, by regulating HOX gene expression. It is involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. JMJD3 can also interact with and demethylate p53, resulting in its stabilization and localization to the nucleus in mouse embryo fibroblasts during neural stem cell differentiation.

Trial Size, IAV

122937251

Human JMJD3 has 2 isoforms, including isoform 1 (1682aa, 181kD) and isoform 2 (1643aa, 177kD). Mouse JMJD3 has one isoform (1641aa, 176kD) and rat JMJD3 also has one isoform (1356aa, 146kD). 6657 can detect human, mouse and rat.

PRS-1201-0.1mg

PRS-1204-0.1mg

1 mg/mL

WB: 0.25-4 μ g/mL; ICC: 2.5 μ g/mL; IF: 20 μ g/mL.
Antibody validated: Western Blot in human, mouse and rat samples; Immunocytochemistry in human samples; Immunofluorescence in human samples. All other applications and species not yet tested.

Anti-JMJD3 antibody (6657) was raised against a peptide corresponding to 16 amino acids near the carboxy terminus of human JMJD3.

The immunogen is located within amino acids 1370-1420 of JMJD3.

lysine (K)-specific demethylase 6B

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.