PHOX2B Antibody

Primary Antibodies

PHOX2B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

PHOX2B Antibody: PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.

Trial Size

12707580

PRS-1210-0.1mg

PHOX2B Antibody is supplied in PBS containing 0.02% sodium azide.

Predicted species reactivity based on immunogen sequence: Chicken: (75%), Bovine: (79%)

PHOX2B antibody was raised against a 15 amino acid synthetic peptide near the center of human PHOX2B.

The immunogen is located within amino acids 130 - 180 of PHOX2B.

paired-like homeobox 2b

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.