SCUBE3 Antibody

Blue Ice

109 kDa

SCUBE3 Antibody: SCUBE3 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and is highly expressed in primary osteoblasts and bones, and to a lesser extent in heart. Other studies have shown that overexpression of SCUBE3 in mice induced cardiac hypertrophy, suggesting that it may also play a role in the regulation of cardiac growth.. SCUBE3 has been shown to be an endogenous TGF-β receptor ligand and is thought to promote lung cancer cell mobility and invasiveness. In lung cancer cells, the secreted SCUBE3 protein was cleaved by MMP2 and MMP9, allowing the activation of the TGF-β receptor, the increase of Smad2/3 transcriptional activity and the upregulation of expression of proteins such as TGF-β 1, VEGF, Snail, and Slug.

Trial Size

31377568

PRS-1405-0.1mg

1 mg/mL

SCUBE3 antibody can be used for detection of SCUBE3 by Western blot at 1 - 2 μ g/mL. For immunofluorescence start at 20 μ g/mL.
Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.

SCUBE3 antibody was raised against a 15 amino acid synthetic peptide near the center of human SCUBE3.

The immunogen is located within amino acids 210 - 260 of SCUBE3.

signal peptide, CUB and EGF-like domain-containing protein 3 precursor

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.