LMX1A Antibody

ArtNr	PRS-7087-0.1mg
Hersteller	ProSci
Menge	0.1 mg
Quantity options	0.02 mg 0.1 mg
Kategorie	Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, ICC, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	Failli V, Bachy I and Retaux S. Expression of the LIM-homeodomain gene Lmx1a (dreher) during development of the mouse nervous system. Mech. Dev. 2002; 118:225-8. Nakatani T, Kumai M, Mizuhara E, et al. Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon. Dev. Biol. 2010; 339:101-13. Chizhikov VV and Millen KJ. Control of roof plate formation by LMX1A in the developing spinal cord. Development 2004; 131:2693-705. Lin CK, Chao TK, Lai HC, et al. LMX1A as a prognostic marker in ovarian mucinous cystadenocarcinoma. Am. J. Clin. Pathol. 2012; 137:971-7.
NCBI	LMX1A
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	LMX1A Antibody: LMX1, LMX1.1, LIM homeobox transcription factor 1-alpha
Lieferbar
Manufacturer - Applications	LMX1A antibody can be used for detection of LMX1A by Western blot at 1 - 2 μg/mL. Antibody can also be used for Immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL. Antibody validated: Western Blot in rat samples; Immunohistochemistry in human and mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.
Shipping Temperature	Blue ice
Storage Conditions	LMX1A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight	Predicted: 42kD Observed: 45 kD
Manufacturer - Research Area	Stem Cell
Background	LMX1A Antibody: The LIM homeobox transcription factor 1 (LMX1A) belongs to the LIM-homeodomain family. Members of this family are known to be important for pattern formation during development. LMX1A binds an A/T-rich sequence and functions in the nucleus as a transcriptional activator to the insulin gene promoter. In the developing embryo, LMX1A is expressed along the neuraxis and leads to the development of the roof plate of the vertebrae. While LMX1A is crucial for the differentiation of dopamine neurons, the related LMX1B appears to be important for both the development and the survival of these cells. It has been suggested that LMX1A might be a useful biomarker or risk factor in tumor aggressiveness.
Protein Gi #	28893581
Purification	LMX1A Antibody is affinity chromatography purified via peptide column.
Isoforms	Human LMX1A has two isoforms, including isoform 1 (382aa, 42.7kD) and isoform 2 (133aa, 14.6kD). Mouse LMX1A one isoform (382aa, 42.9kD), and ratt LMX1A has one isoform (382aa, 42.8kD). 7087 can detect human, mouse and rat.
Positive Control 1	PRS-1375-0.1mg
Positive Control 2	PRS-1407-0.1mg
Positive Control 3	PRS-1467-0.1mg
Concentration	1 mg/ml
Buffer	LMX1A Antibody is supplied in PBS containing 0.02% sodium azide.
Application Note	WB: 1-2 μg/mL; ICC/IF: 10-20 μg/mL; IHC-P: 1-5 μg/mL. Antibody validated: Western Blot in human, mouse and rat samples; Immunocytochemistry in human samples; Immunohistochemistry in human, mouse, and rat samples. All other applications and species not yet tested.
Homology	Predicted species reactivity based on immunogen sequence: Chicken: (92%)
Manufacturer - Specificity	At least two isoforms are known to exist. This antibody is predicted to not cross-react with LMX1B.
Immunogen	Rabbit polyclonal LMX1A antibody was raised against a 16 amino acid peptide near the carboxy terminus of human LMX1A. The immunogen is located within amino acids 300 - 350 of LMX1A.
Clonality	Polyclonal
NCBI Official Name	LIM homeobox transcription factor 1, alpha
NCBI Organism	homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

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