ULK1 Antibody

ArtNr	PRS-7335-0.1mg
Hersteller	ProSci
Menge	0.1 mg
Quantity options	0.02 mg 0.1 mg
Kategorie	Antibodies Cell Biology Cell Status Immunohistochemistry Western Blot ELISA Immunofluorescence Autophagy Primary Antibodies
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	Suzuki K, Kubota Y, Sekito T, et al. Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes to Cells 2007; 12:209–18. Lee EJ and Tournier C. The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy. Autophagy 2011; 7:689-95. Yan J, Kuroyanagi H, Tomemori T, et al. Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains. Oncogene 1999; 18:5850–9. Bach M, Larance M, James DE, et al. The serine/threonine kinase ULK1 is a target of multiple phosphorylation events. Biochem. J. 2011; 440:283-91.
NCBI	ULK1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ULK1 Antibody: ATG1,ATG1A,UNC51,hATG1,Unc51.1,KIAA0722,Autophagy-related protein 1 homolog,ATG1
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Primary Antibodies
Shipping Temperature	Blue Ice
Storage Conditions	ULK1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Molecular Weight	Predicted: 116 kDa Observed: 105 kDa
Manufacturer - Research Area	Autophagy
Background	ULK1 Antibody: ULK1, also known as ATG1, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK1 results in a severe defect in the autophagy pathway. ULK1 is highly conserved among eukaryotes, and are the Unc-51-like kinases, ULK1 and ULK2 in mammals. ULK1 is ubiquitously expressed and involved in autophagy in response to starvation. It is the target of the TOR kinase signaling pathway that regulates autophagy through the control of phosphorylation status of ATG13. ULK1 also plays a role early in neuronal differentiation.
By Type	Autophagy
Badges	Trial Size
Modifications	None
Protein Gi #	4507831
Purification	ULK1 Antibody is affinity chromatography purified via peptide column.
Positive Control 1	PRS-1463-0.1mg
Concentration	1 mg/mL
Buffer	ULK1 Antibody is supplied in PBS containing 0.02% sodium azide.
Application Note	ULK1 Antibody can be used for detection of ULK1 by Western blot at 1 μ g/mL. Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Manufacturer - Specificity	Two alternatively spliced transcript variants encoding different isoforms have been identified. ULK1 antibody is predicted to not cross-react with ULK2.
Immunogen	ULK1 antibody was raised against a 16 amino acid peptide near the center of human ULK1 . The immunogen is located within amino acids 350 - 400 of ULK1.
Clonality	Polyclonal
NCBI Official Name	unc-51-like kinase 1 (C. elegans)
NCBI Organism	homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher.

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