GRK6 Antibody

Blue Ice

Predicted: 63 kDa
Observed: 63 kDa

The G protein–coupled receptor kinases (GRKs) are a versatile family of kinases that play a critical role in cancer metastasis through their regulation of G-protein coupled receptors (GPCRs) involved in growth factor mediated cell migration (1, 2). Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state (1). GRK6 is one of 7 members of the GRK serine/threonine kinase subfamily, which has been shown to modulate the Wnt signaling pathway via phosphorylation of LRP6 (3, 4), and the insulin-like growth factor signaling pathway (4). GRK6 may also play a role in immune system function (5).

Trial Size

51896039

PRS-1468-0.1mg

1 mg/mL

GRK6 antibody can be used for detection of GRK6 by Western blot at 1 - 2 μ g/ml. Antibody can also be used for Immunohistochemistry starting at 5 μ g/mL. For immunofluorescence start at 20 μ g/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

GRK6 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human GRK6.

The immunogen is located within the last 50 amino acids of GRK6.

G protein-coupled receptor kinase 6

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.