RHOT1 Antibody

ArtNr	PRS-8027-0.02mg
Hersteller	ProSci
Menge	0.02 mg
Quantity options	0.02 mg 0.1 mg
Kategorie	Neuroscience Neuroinflammation Metabolism Diabetes Neural Mitochondrial Function Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	Fransson A, Ruusala A, and Aspenstrom P. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. J. Biol. Chem. 2003; 278:6495-502. Macaskill AF, Brickley K, Stephenson FA, et al. GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons. Mol. Cell. Neurosci. 2009;40:301–12. Weihofen A, Thomas KJ, Ostaszewski B, et al. Pink1 forms a multi-protein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking. Biochemistry 2009; 48:2045-54. Wang X, Winter D, Ashrafi G, et al. PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell 2011; 147:893-906.
NCBI	RHOT1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Ras homolog family member T1,mitochondrial Rho GTPase 1,ARHT1,MIRO-1,MIRO1,MIRO
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Primary Antibodies
Shipping Temperature	Blue Ice
Storage Conditions	RHOT1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Molecular Weight	Predicted: 76 kDa Observed: 78 kDa
Manufacturer - Research Area	Neuroscience
Background	The Ras homolog family member T1 (RHOT) is an atypical Rho Ca2+-binding GTPase that localizes to the mitochondria (1). RHOT1, the related protein RHOT2, the adaptor protein Milton, and the PTEN induced putative kinase 1 (PINK1), form a complex that is involved in axonal transport of mitochondria (2, 3). Both PINK1 and Parkin target RHOT1 for phosphorylation and degradation, causing the arrest of mitochondrial motility (4).
By Type	Neuroscience
Badges	Trial Size
Modifications	None
Protein Gi #	75750480
Purification	RHOT1 antibody is affinity chromatography purified via peptide column.
Positive Control 1	PRS-1463-0.1mg
Concentration	1 mg/mL
Buffer	RHOT1 antibody is supplied in PBS containing 0.02% sodium azide.
Application Note	RHOT1 antibody can be used for detection of RHOT1 by Western blot at 1 - 2 μ g/ml. Antibody can also be used for immunohistochemistry starting at 5 μ g/mL. For immunofluorescence start at 20 μ g/mL. Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Homology	Predicted species reactivity based on immunogen sequence: Bovine: (100%), Chicken: (81%)
Manufacturer - Specificity	RHOT1 antibody is human, mouse and rat reactive. At least three isoforms of RHOT1 are known to exist; this antibody will detect all three isoforms.
Immunogen	RHOT1 antibody was raised against a 15 amino acid peptide near the amino terminus of human RHOT1. The immunogen is located within amino acids 40 - 90 of RHOT1.
Clonality	Polyclonal
NCBI Official Name	ras homolog family member T1
NCBI Organism	homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher.

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