LAG3 Antibody

Immunology

LAG3 antibody was raised against a peptide corresponding to 15 amino acids near the carboxy terminus of human LAG3.

The immunogen is located within amino acids 470 - 520 of LAG3.

Cat. No. 1304 - Human Liver Tissue Lysate

Predicted: 55 kDa

Observed: 40 kDa

Polyclonal

Unconjugated

1 mg/mL

Cat. No. 8657P - LAG3 Peptide

None

NP_002277

3902

LAG3

Homo sapiens

The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2). It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4). LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy (5).

Triebel F. LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination. Trends Immunol 2003; 24:619–22.

Workman CJ, Vignali DA. The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells. Eur J Immunol 2003; 33:970–9.

Immunohistochemistry of LAG3 in human tonsil tissue with LAG3 antibody at 2 μ g/ml.