Apaf-1 Antibody [5E11]

IgG1, k

Apaf-1 monoclonal antibody can be stored at -20˚ C, stable for one year.

Apaf-1 Monoclonal Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologous of the key cell death gene CED-4 in C. elegans was identified recently from human and mouse and designated Apaf1 for apoptosis protease-activating factor 1. Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf1 can also associate with caspase-4 and caspase-8. Apaf1 transcript is ubiquitously expressed in human tissues.

Trial Size

2330015

PRS-1204-0.1mg

1 mg/mL

Apaf1 antibody can be used for detection of Apaf1 by immunohistochemistry at 0.5 mg/mL. Apaf1 has not been confirmed for use in Western Blot.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Monoclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.