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DC-SIGN Antibody [5D7]

DC-SIGN Antibody [5D7]

ArtNr	PRS-PM-2347-0.1mg
Hersteller	ProSci
Menge	0.1 mg
Quantity options	0.02 mg 0.1 mg
Kategorie	Neuroscience Aging & Neurological Disorders Antibodies Cell Biology Cell Movement Cell Adhesion Immunohistochemistry Western Blot ELISA Primary Antibodies
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, ELISA, IHC-P
Clon	5D7
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1
Konjugat/Tag	Unconjugated
Citations	Geijtenbeek TB, Kwon DS, Torensma R, et al. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 2000; 100:587-97. Pohlmann S, Baribaud F, Lee B, et al. DC-SIGN interactions with human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus. J. Virol. 2001; 75:4664-72. Geijtenbeek TB, Torensma R, van Vliet SJ, et al. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 2000; 100:575-85. Soilleux EJ, Barten R, Trowsdale J. DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13. J. Immunol. 2000; 165:2937-42.
NCBI	CD209
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	DC-SIGN Antibody [5D7]: CDSIGN,CLEC4L,DC-SIGN,DC-SIGN1
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Primary Antibodies
Shipping Temperature	Blue Ice
Storage Conditions	DC-SIGN monoclonal antibody can be stored at -20˚ C, stable for one year.
Molecular Weight	Predicted: 44 kDa Observed: 47 kDa
Manufacturer - Research Area	Infectious Disease
Background	DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.
By Type	Infectious Disease
Badges	Trial Size
Modifications	None
Protein Gi #	46396012
Purification	DC-SIGN Monoclonal Antibody is Protein A purified.
Positive Control 1	PRS-1314-0.1mg
Positive Control 2	PRS-1369-0.1mg
Concentration	1 mg/mL
Buffer	DC-SIGN Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Application Note	DC-SIGN antibody can be used for detection of DC-SIGN in Western Blot at 1 μ g/mL and in immunohistochemistry at 5 - 10 μ g/mL. Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Immunogen	A recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN.
Clonality	Monoclonal
NCBI Official Name	CD209 molecule
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 0.1 mg

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Lieferung vsl. bis 06.11.2025