Anti-Butyryl-Histone H3 (Lys14) Rabbit mAb

WB, ICC/IF, ChIP

Histone H3

Store at -20°C. Avoid freeze/thaw cycles.

Stable for 12 months from date of receipt/reconstitution.

H3 is core component of nucleosome. Nucleosomes wrap and compact DNAinto chromatin, limiting DNA accessibility to the cellular machineries whichrequire DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are subjected to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitylation, etc. Butyrylation of histones marks active promoters and competes with histone acetylation, which occurs during late

Anti-Butyryl-Histone H3 (Lys14) Rabbit mAb detects histone H3 only when it is butyrylated at Lys14. 

Butyryl

Butyrylated human histone H3 (Lys14) peptide

H3 is core component of nucleosome. Nucleosomes wrap and compact DNA
into chromatin, limiting DNA accessibility to the cellular machineries which
require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are subjected to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitylation, etc. Butyrylation of histones marks active promoters and competes with histone acetylation, which occurs during late