Anti-Succinyl-Histone H3 (Lys79) Rabbit pAb

Primary Antibodies

Histone H3

Store at -20°C. Avoid freeze/thaw cycles.

Stable for 12 months from date of receipt/reconstitution.

Succinylation is a post-translational modification where a succinyl group (-CO-CH2-CH2-COOH) is added to a lysine residue in proteins, including histones. This addition of succinyl group changes lysine's charge from +1 to -1 (at physiological pH) and introduces a relatively large structural moiety (100 Da), bigger than acetylation (42 Da) or methylation (14 Da). It is expected to lead to more significant changes in protein structure and function. Lysine succinylation, particularly at Lys79 on histone H3, is mediated by the enzyme KAT2A and has implications in tumor growth and disease progression. KAT2A-mediated succinylation is also observed in hepatitis B virus (HBV) infection, impacting HBV replication and epigenetic regulation.

Anti-Succinyl-Histone H3 (Lys79) Rabbit pAb detects histone H3 only when it is succinylated at Lys79. 

Succinyl

Succinylated human histone H3 (Lys79) peptide

Succinylation is a post-translational modification where a succinyl group (-CO-CH2-CH2-COOH) is added to a lysine residue in proteins, including histones. This addition of succinyl group changes lysine's charge from +1 to -1 (at physiological pH) and introduces a relatively large structural moiety (100 Da), bigger than acetylation (42 Da) or methylation (14 Da). It is expected to lead to more significant changes in protein structure and function. Lysine succinylation, particularly at Lys79 on histone H3, is mediated by the enzyme KAT2A and has implications in tumor growth and disease progression. KAT2A-mediated succinylation is also observed in hepatitis B virus (HBV) infection, impacting HBV replication and epigenetic regulation.