ArtNr |
PTM-6401 |
Hersteller |
PTM Biolabs
|
Menge |
100 ul |
Kategorie |
|
Typ |
Antibody Monoclonal |
Format |
Lyophilized powder |
Applikationen |
WB, IHC-P |
Clon |
JRMR-10764-13 |
Specific against |
Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus) |
Host |
Rabbit |
Isotype |
IgG |
Konjugat/Tag |
Unconjugated |
Citations |
Yaping Yu, et al. Dendrobium nobile active ingredient Dendrobin A against hepatocellular carcinoma via inhibiting nuclear factor kappa-B signaling. BIOMEDICINE & PHARMACOTHERAPY, 2024. https://www.sciencedirect.com/science/article/pii/S0753332224008977. |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
NFKBIA, IKBA, MAD3, NFKBI |
Versandbedingung |
Raumtemperatur |
Lieferbar |
|
Manufacturer - Type |
Primary Antibodies |
Manufacturer - Category |
Uncategorized |
Manufacturer - Targets |
IkB alpha |
Shipping Temperature |
Ambient temperature |
Storage Conditions |
Store at -20°C. Avoid freeze/thaw cycles. |
Stability |
Stable for 12 months from date of receipt/reconstitution. |
Manufacturer - Research Area |
Signal Transduction, Immunology, Cancer |
Product description |
NF-kappa-B inhibitor alpha (IKB alpha) inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, IKB alpha becomes phosphorylated promoting itself ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. |
Purification Method |
Protein A purified |
Formula |
PBS, Glycerol, BSA |
PTM |
Phospho |
Modification Site |
Ser32, Ser36 |
Clonality |
Recombinant Monoclonal |
Background |
NF-kappa-B inhibitor alpha (IKB alpha) inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, IKB alpha becomes phosphorylated promoting itself ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. |
Cellular Localization |
Nucleus, cytoplasm |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.