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Anti-Phospho-IkB alpha (Ser32/36) Rabbit mAb

Anti-Phospho-IkB alpha (Ser32/36) Rabbit mAb

Item no.	PTM-6401
Manufacturer	PTM Biolabs
Amount	100 ul
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	Lyophilized powder
Applications	WB, IHC-P
Clone	JRMR-10764-13
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	Yaping Yu, et al. Dendrobium nobile active ingredient Dendrobin A against hepatocellular carcinoma via inhibiting nuclear factor kappa-B signaling. BIOMEDICINE & PHARMACOTHERAPY, 2024. https://www.sciencedirect.com/science/article/pii/S0753332224008977.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	NFKBIA, IKBA, MAD3, NFKBI
Shipping condition	Room temperature
Available
Manufacturer - Type	Primary Antibodies
Manufacturer - Category	Uncategorized
Manufacturer - Targets	IkB alpha
Shipping Temperature	Ambient temperature
Storage Conditions	Store at -20°C. Avoid freeze/thaw cycles.
Stability	Stable for 12 months from date of receipt/reconstitution.
Manufacturer - Research Area	Signal Transduction, Immunology, Cancer
Product description	NF-kappa-B inhibitor alpha (IKB alpha) inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, IKB alpha becomes phosphorylated promoting itself ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Purification Method	Protein A purified
Formula	PBS, Glycerol, BSA
PTM	Phospho
Modification Site	Ser32, Ser36
Clonality	Recombinant Monoclonal
Background	NF-kappa-B inhibitor alpha (IKB alpha) inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, IKB alpha becomes phosphorylated promoting itself ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Cellular Localization	Nucleus, cytoplasm

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 7/24/2025

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