Anti-Synaptobrevin (VAMP)

Monoclonal Antibody

Wet Ice

The antibody has been directly tested for reactivity in human, pig, hamster, rat, rabbit, mouse, and bovine.
Western blot of rat brain lysate showing specific immunolabeling of the ~ 16k synaptobrevin protein.

Liquid. 100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

Synaptobrevin (aka VAMP) is an integral membrane protein of synaptic vesicles that plays a major role in the formation of larger SNARE complexes, along with SNAP-25 and syntaxin. Synaptobrevin has been shown to be essential for two fast synapse-specific membrane trafficking processes: fast exocytosis for neurotransmitter release and fast endocytosis that mediates rapid recycling of synaptic vesicles (Deak et al., 2004). Decreased levels of synaptobrevin in human hippocampus and cortex have been correlated with cognitive defects in Alzheimer's disease (Sze et al., 2000).

Vesicle-associated membrane protein 1

Purified culture supernatant.

Cow; Human; Mouse; Pig; Rabbit; Rat