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Anti-Synaptobrevin (VAMP)

Anti-Synaptobrevin (VAMP)

Item no.	OAPC00064
Manufacturer	AVIVA Systems Biology
Amount	100 ul
Category	Neuroscience Neural Signaling Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IHC
Clone	SP10
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Rabbit (Oryctolagus cuniculus), Pig (Porcine, Sus scrofa domesticus), Cow (Bos taurus)
Host	Mouse
Isotype	IgM
Citations	DeÃƒÂ¡k F, Schoch S, Liu X, SÃƒÂ¼dhof TC, Kavalali ET (2004) Synaptobrevin is essential for fast synaptic-vesicle endocytosis. Nat Cell Biol. 2004 Nov;6(11):1102-8. Sze CI, Bi H, Kleinschmidt-DeMasters BK, Filley CM, Martin LJ (2000) Selective regional loss of exocytotic presynaptic vesicle proteins in Alzheimer's disease brains. J Neurol Sci.175(2):81-90. Honer, W. G., Hu, L. & Davies, P. Human synaptic proteins with a heterogeneous distribution in cerebellum and visual cortex (1993). Brain Research 609, 9-20.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	SYB1,CMS25,SPAX1,VAMP-1
Shipping Condition	Cool pack
Available
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Monoclonal Antibodies/Pan Specific, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	~16kDa
Manufacturer - Application Additional Information	The antibody has been directly tested for reactivity in human, pig, hamster, rat, rabbit, mouse, and bovine. Western blot of rat brain lysate showing specific immunolabeling of the ~ 16k synaptobrevin protein.
Gene symbol	VAMP1/2
Product format	Liquid. 100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
Reconstitution and storage	Store at -20C; stable for at least one year.
Description of target	Synaptobrevin (aka VAMP) is an integral membrane protein of synaptic vesicles that plays a major role in the formation of larger SNARE complexes, along with SNAP-25 and syntaxin. Synaptobrevin has been shown to be essential for two fast synapse-specific membrane trafficking processes: fast exocytosis for neurotransmitter release and fast endocytosis that mediates rapid recycling of synaptic vesicles (Deak et al., 2004). Decreased levels of synaptobrevin in human hippocampus and cortex have been correlated with cognitive defects in Alzheimer's disease (Sze et al., 2000).
Protein accession_num	NP_055046.1
Protein name	Vesicle-associated membrane protein 1
Clonality	Monoclonal
Purification	Purified culture supernatant.
Immunogen	Synaptic immunoprecipitate (crude) from human brain.
Homology	Cow; Human; Mouse; Pig; Rabbit; Rat
Manufacturer - Specificity	The antibody is specific for the ~16kDa synaptobrevin protein in Western blots of rat brain lysate. The antibody has also been demonstrated to work in immunohistochemistry on formalin fixed, vibratome sections, but does not work on paraffin sections.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 1/29/2026

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