Anti-Thyroid Hormone Receptor, alpha1/ alpha2 -Isotype (OAPC00012)

THRA

ca.50kDa Alpha1 & ca.58kDa Alpha3

7067

Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TR alpha 1, TR alpha 2, TR beta 1 and TR beta 2. TR alpha 1, TR beta 1 and TR beta 2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).

Prepared from mouse ascites by ammonium sulfate precipitation followed by affinity purification on a protein G column.

Peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, alpha 1/ alpha 2-isotype.