Anti-Thyroid Hormone Receptor, alpha1/ alpha2 -Isotype

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Wet Ice

The antibody has been directly tested for reactivity in Western blots with human and rat tissue. It is anticipated that the antibody will react with canine, mouse and non-human primates based on the fact that these species have 100% homology with the amino acid sequence used as antigen.

Liquid. 100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TR alpha 1, TR alpha 2, TR beta 1 and TR beta 2. TR alpha 1, TR beta 1 and TR beta 2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).

NP_003241

Monoclonal

Peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, alpha 1/ alpha 2-isotype.

Specific for the ~50k TR- alpha 1 and the ~58k TR- alpha 2 protein.