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Anti-TRAP1 (9B6) Antibody

Anti-TRAP1 (9B6) Antibody

ArtNr	OAED00214
Hersteller	AVIVA Systems Biology
Menge	50 ug
Kategorie	Oncology Neuroscience Neuroinflammation Metabolism Cholesterol & Lipid Metabolism Neural Mitochondrial Function Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Lymphoma Myeloma Melanoma Sarcoma Cell Biology Cell Status Adenocarcinoma Western Blot Autophagy Primary Antibodies
Typ	Antibody Monoclonal
Applikationen	WB
Clon	9B6
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Mouse
Isotype	IgG2a
Purity	Protein G-affinity purified.<br/>
Citations	Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer: I. Leav, et al.; Am. J. Pathol. 176, 393 (2010), Abstract; TRAP1, a novel mitochondrial chaperone responsible for multi-drug resistance and protection from apoptotis in human colorectal carcinoma cells: E. Costantino, et al.; Cancer Lett. 279, 39 (2009), Abstract; Regulation of heat shock protein 90 ATPase activity by sequences in the carboxyl terminus: B.A. Owen, et al.; J. Biol. Chem. 277, 7086 (2002), Abstract; The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties: S.J. Felts, et al.; J. Biol. Chem. 275, 3305 (2000), Abstract; The charged region of Hsp90 modulates the function of the N-terminal domain: T. Scheibel, et al.; PNAS U.S.A. 96, 1297 (1999), Abstract; Oligomeric forms of the 90-kDa heat shock protein: T. Nemoto & N. Sato; Biochem. J. 330, 989 (1998), Abstract; A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock: C.F. Chen, et al.; Mol. Cell. Biol. 1, 4691 (1996), Abstract;
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	heat shock protein 75 kDa,mitochondrial;HSP 75;HSP75;HSP90L;testicular tissue protein Li 209;TNFR-associated protein 1;TRAP-1;tumor necrosis factor type 1 receptor-associated protein.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	Western Blot (1:500, ECL) Optimal conditions must be determined individually for each application.
Gene symbol	TRAP1
Gene Fullname	TNF receptor associated protein 1
Reconstitution and storage	Long Term Storage : -20C
Description of target	Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.
Protein name	Heat shock protein 75 kDa, mitochondrial
Clonality	Monoclonal
Immunogen	Recombinant human TRAP1.
Manufacturer - Specificity	Recognizes human and mouse TRAP1. Detects a band of ~72kDa by Western blot.
Formulation	Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Concentration	1.0mg/ml

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 50 ug

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Lieferung vsl. bis 29.01.2026

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