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Anti-TRAP1 (9B6) Antibody

Anti-TRAP1 (9B6) Antibody

Item no.	OAED00214
Manufacturer	AVIVA Systems Biology
Amount	50 ug
Category	Oncology Neuroscience Neuroinflammation Metabolism Cholesterol & Lipid Metabolism Neural Mitochondrial Function Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Lymphoma Myeloma Melanoma Sarcoma Cell Biology Cell Status Adenocarcinoma Western Blot Autophagy Primary Antibodies
Type	Antibody Monoclonal
Applications	WB
Clone	9B6
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Mouse
Isotype	IgG2a
Purity	Protein G-affinity purified.<br/>
Citations	Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer: I. Leav, et al.; Am. J. Pathol. 176, 393 (2010), Abstract; TRAP1, a novel mitochondrial chaperone responsible for multi-drug resistance and protection from apoptotis in human colorectal carcinoma cells: E. Costantino, et al.; Cancer Lett. 279, 39 (2009), Abstract; Regulation of heat shock protein 90 ATPase activity by sequences in the carboxyl terminus: B.A. Owen, et al.; J. Biol. Chem. 277, 7086 (2002), Abstract; The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties: S.J. Felts, et al.; J. Biol. Chem. 275, 3305 (2000), Abstract; The charged region of Hsp90 modulates the function of the N-terminal domain: T. Scheibel, et al.; PNAS U.S.A. 96, 1297 (1999), Abstract; Oligomeric forms of the 90-kDa heat shock protein: T. Nemoto & N. Sato; Biochem. J. 330, 989 (1998), Abstract; A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock: C.F. Chen, et al.; Mol. Cell. Biol. 1, 4691 (1996), Abstract;
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	heat shock protein 75 kDa,mitochondrial;HSP 75;HSP75;HSP90L;testicular tissue protein Li 209;TNFR-associated protein 1;TRAP-1;tumor necrosis factor type 1 receptor-associated protein.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	Western Blot (1:500, ECL) Optimal conditions must be determined individually for each application.
Gene symbol	TRAP1
Gene Fullname	TNF receptor associated protein 1
Reconstitution and storage	Long Term Storage : -20C
Description of target	Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.
Protein name	Heat shock protein 75 kDa, mitochondrial
Clonality	Monoclonal
Immunogen	Recombinant human TRAP1.
Manufacturer - Specificity	Recognizes human and mouse TRAP1. Detects a band of ~72kDa by Western blot.
Formulation	Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Concentration	1.0mg/ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 1/29/2026

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