MyD88 Antibody

ArtNr	OAPB01342
Hersteller	AVIVA Systems Biology
Menge	0.1 mg
Kategorie	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Diabetes Glucose Homeostasis Antibodies By Cell Type Hematology Leukemia Lymphoma Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining Neurodegeneration Markers
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, IF, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Mouse
Konjugat/Tag	Unconjugated
Citations	Muzio M, Ni J, Feng P, et al. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 1997; 278:1612-5.;Adachi O, Kawai T, Takeda K, et al. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 1998; 9:143-50.; Medzhitov R, Preston-Hurlburt P, Kopp E, et al. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell 1998; 2:253-8.;Kawai T, Adachi O, Ogawa T, et al. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 1999; 11:115-22.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	IMD68;mutant myeloid differentiation primary response 88;MYD88D;myeloid differentiation primary response 88;myeloid differentiation primary response gene (88);myeloid differentiation primary response protein MyD88.
Similar products	MyD88
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Applications	Enzyme-linked immunosorbent assay\|Immunofluorescence\|Immunohistochemistry-Paraffin\|Western blot
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Manufacturer - Host	MyD88 monoclonal antibody was raised in mouse.Please use anti-mouse secondary antibodies.
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	MyD88 antibody can be used for detection of MyD88 by Western blot at 2 â€“ 4 ug/mL. (Optimal dilution should be determined by user)
Gene symbol	MYD88
Gene Fullname	MYD88 innate immune signal transduction adaptor
Product format	Liquid. MyD88 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution and storage	MyD88 monoclonal antibody can be stored at 4C, stable for one year.
Description of target	Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:24316379, PubMed:19506249). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).
Protein accession_num	https://www.ncbi.nlm.nih.gov/protein/AAC50954
Protein name	MyD88 [Homo sapiens]\|Myeloid differentiation primary response protein MyD88
Clonality	Monoclonal
Purification	Protein A Purified
Immunogen	Mouse monoclonal MyD88 antibody was raised against a recombinant protein corresponding to amino acids 176 to 280 of human MyD88.
Homology	Human; Mouse
Concentration	1 mg/ml

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Menge: 0.1 mg

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