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Anti-P27kip Polyclonal Antibody (OAAI00157)

Anti-P27kip Polyclonal Antibody (OAAI00157)

ArtNr	OAAI00157
Hersteller	AVIVA Systems Biology
Menge	100 ug
Kategorie	Oncology Antibodies By Cell Type Carcinoma Hematology Lymphoma Melanoma Sarcoma Immunohistochemistry Immunoprecipitation Western Blot Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	WB, IP, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	KIP1, MEN4, CDKN4, MEN1B, P27KIP1
Similar products	KIP1, CDKN4, MEN1B, MEN4, P27KIP1
Lieferbar
Gene symbol	CDKN1B
Molecular weight	ca.27 kDa
Product format	Liquid. supplied in sterile Tris buffered saline (pH 7.2) containing antibody stabilizer
Gene id	1027
Reconstitution and storage	The antibodies are stable for 12 months from date of receipt when stored at -20° C to -70° C. The antibodies can be stored at 2° C-8° C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Description of target	The p27Kip1 gene codes for a cyclin-dependent kinase inhibitor implicated in G1 arrest by transforming growth factor beta, cell-cell contact, agents that elevate cyclic AMP, and the growth-inhibitory drug rapamycin. p27 binds to and inhibits complexes formed by cyclin E-cdk2, cyclin A-cdk2, and cyclin D-cdk4. The involvement of p27 in the negative regulation of cell proliferation suggests that it may also function as a tumor suppressor gene. The degradation of p27, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
Purification	Purified by Site-specific Epitope Affinity Purification
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to the C-terminus of human p27. This sequence is identical among human, rat, mouse, bovine, dog origins.
Drywet	Wet Ice

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

OAAI00157-datasheet.pdf

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Einfache Bestellung Periodische Bestellung

Menge: 100 ug

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Lieferung vsl. bis 11.09.2025

Express-Lieferung: 13 Tage sparen

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