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Anti-P27kip Polyclonal Antibody (OAAI00157)

Anti-P27kip Polyclonal Antibody (OAAI00157)

Item no.	OAAI00157
Manufacturer	AVIVA Systems Biology
Amount	100 ug
Category	Oncology Antibodies By Cell Type Carcinoma Hematology Lymphoma Melanoma Sarcoma Immunohistochemistry Immunoprecipitation Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	WB, IP, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	KIP1, MEN4, CDKN4, MEN1B, P27KIP1
Similar products	KIP1, CDKN4, MEN1B, MEN4, P27KIP1
Available
Gene symbol	CDKN1B
Molecular weight	ca.27 kDa
Product format	Liquid. supplied in sterile Tris buffered saline (pH 7.2) containing antibody stabilizer
Gene id	1027
Reconstitution and storage	The antibodies are stable for 12 months from date of receipt when stored at -20° C to -70° C. The antibodies can be stored at 2° C-8° C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Description of target	The p27Kip1 gene codes for a cyclin-dependent kinase inhibitor implicated in G1 arrest by transforming growth factor beta, cell-cell contact, agents that elevate cyclic AMP, and the growth-inhibitory drug rapamycin. p27 binds to and inhibits complexes formed by cyclin E-cdk2, cyclin A-cdk2, and cyclin D-cdk4. The involvement of p27 in the negative regulation of cell proliferation suggests that it may also function as a tumor suppressor gene. The degradation of p27, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
Purification	Purified by Site-specific Epitope Affinity Purification
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to the C-terminus of human p27. This sequence is identical among human, rat, mouse, bovine, dog origins.
Drywet	Wet Ice

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 9/11/2025

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