JAK1 Antibody

ArtNr	OAAI00395
Hersteller	AVIVA Systems Biology
Menge	100 ug
Kategorie	Oncology Neuroscience Neural Lineage Markers Neural Transcription Factors Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Adenocarcinoma Myelofibrosis Flow Cytometry Immunohistochemistry Immunoprecipitation Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, FC, IP, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	Howard,O.M., Dean,M., Young,H., Ramsburg,M., Turpin,J.A., Michiel,D.F., Kelvin,D.J., Lee,L. and Farrar,W.L. Characterization of a class 3 tyrosine kinase . Oncogene 7 (5), 895-900 (1992)
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	AIIDE;JAK1A;JAK1B;JTK3;tyrosine-protein kinase JAK1.
Similar products	JAK1A, JAK1B, JTK3
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Shipping Temperature	Wet Ice
Molecular Weight	130
Manufacturer - Application Additional Information	WB: 0.1-1 ug/ml \| ELISA: 0.01-0.1 ug/ml \| IP: 2-5 ug/ml \| IHC: 2-10 ug/ml \| FC: Not tested
Gene symbol	JAK1
Gene Fullname	Janus kinase 1
Product format	Liquid. This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
Reconstitution and storage	The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Description of target	The Janus tyrosine kinase family is consists of four members, JAK1, JAK2, JAK3 and Tyk2 ranging from 120-140 kDa. Upon the cytokine ligand binding to its the receptors, the dimerization of the receptors occurs followed by phosphorylation of the receptors. Jak1 plays an essential and nonredundant role in promoting biologic responses induced by a select subset of cytokine receptors. Appropriate activation of JAK1/STAT3 signaling is necessary for cell prolifeRation, survival, and differentiation, but persistent STAT3 activation may result in disease. JAK1/STAT3 pathway is one of the recognized oncogenic signaling pathways that frequently overactivated in a variety of Human tumors. Somatic mutations in JAK1 gene occur in individuals with acute lymphoblastic leukemia (ALL). STAT3 and both JAK1 and 2 are involved in Human colorectal cancer cell growth, survival, invasion, and migRation throμ gh regulation of gene expression.
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	A synthetic peptide derived from the adjacent to C-terminus of JAK1 protein. This sequence is identical in JAK1 from human, rat and mouse origins.
Manufacturer - Specificity	JAK1
Concentration	100ug/200ul

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

OAAI00395-datasheet.pdf

Sicherheitsdatenblatt anfordern

Einfache Bestellung Periodische Bestellung

Menge: 100 ug

lieferbar

Lieferung vsl. bis 11.12.2025

Express-Lieferung: 6 Tage sparen

Vergleichen

Auf den Wunschzettel

Angebot anfordern