ICAM3 Antibody

ArtNr	OAEE00268
Hersteller	AVIVA Systems Biology
Menge	0.1 mg (C100)
Kategorie	Antibodies Flow Cytometry Immunohistochemistry Primary Antibodies Functional Assays
Typ	Antibody Monoclonal
Applikationen	FC, IHC, FA
Clon	MEM-04
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1
Purity	> 95% (by SDS-PAGE)
Citations	Bogoevska V, Nollau P, Lucka L, Grunow D, Klampe B, Uotila LM, Samsen A, Gahmberg CG, Wagener C: DC-SIGN binds ICAM-3 isolated from peripheral human leukocytes through Lewis x residues. Glycobiology. 2007 Mar;17(3):324-33. Arroyo AG, Campanero MR, SÃ¡nchez-Mateos P, Zapata JM, Ursa MA, del Pozo MA, SÃ¡nchez-Madrid F: Induction of tyrosine phosphorylation during ICAM-3 and LFA-1-mediated intercellular adhesion, and its regulation by the CD45 tyrosine phosphatase. J Cell Biol. 1994 Sep;126(5):1277-86. Hernandez-Caselles T, Rubio G, Campanero MR, del Pozo MA, Muro M, Sanchez-Madrid F, Aparicio P: ICAM-3, the third LFA-1 counterreceptor, is a co-stimulatory molecule for both resting and activated T lymphocytes. Eur J Immunol. 1993 Nov;23(11):2799-806. Campanero MR, del Pozo MA, Arroyo AG, SÃ¡nchez-Mateos P, HernÃ¡ndez-Caselles T, Craig A, Pulido R, SÃ¡nchez-Madrid F. ICAM-3 interacts with LFA-1 and regulates the LFA-1/ICAM-1 cell adhesion pathway. J Cell Biol. 1993 Nov;123(4):1007-16.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	CD50;CDW50;ICAM-3;ICAM-R;intercellular adhesion molecule 3.
Similar products	CD50
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Applications	Flow cytometry\|Functional assay\|Immunohistochemistry-Paraffin
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	ICAM3
Gene Fullname	intercellular adhesion molecule 3
Product format	Phosphate buffered saline (PBS), pH 7.4
Reconstitution and storage	2°C to 8°C
Description of target	ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Nucleotide accession_num	NM_002162.3
Protein accession_num	NP_002153.2
Protein name	Intercellular adhesion molecule 3
Clonality	Monoclonal
Purification	Purified
Immunogen	Leukocytes of a patient suffering from LGL-type leukemia.
Manufacturer - Specificity	The antibody MEM-04 reacts with CD50 (ICAM-3), a 120-130 kDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells and Langerhans cells; it is negative on platelets and erythrocytes. The MEM-04 blocks DC-SIGN (CD209) binding to ICAM-3 (epitope in D1).
Formulation	Low endotoxin
Concentration	1 mg/ml
Storage Buffer	Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 um filter sterilized. Endotoxin level is less than 0.01 EU/ug of the protein, as determined by the LAL test.

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Menge: 0.1 mg (C100)

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