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ICAM3 Antibody

ICAM3 Antibody

Item no.	OAEE00268
Manufacturer	AVIVA Systems Biology
Amount	0.1 mg (C100)
Category	Antibodies Flow Cytometry Immunohistochemistry Primary Antibodies Functional Assays
Type	Antibody Monoclonal
Applications	FC, IHC, FA
Clone	MEM-04
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1
Purity	> 95% (by SDS-PAGE)
Citations	Bogoevska V, Nollau P, Lucka L, Grunow D, Klampe B, Uotila LM, Samsen A, Gahmberg CG, Wagener C: DC-SIGN binds ICAM-3 isolated from peripheral human leukocytes through Lewis x residues. Glycobiology. 2007 Mar;17(3):324-33. Arroyo AG, Campanero MR, SÃ¡nchez-Mateos P, Zapata JM, Ursa MA, del Pozo MA, SÃ¡nchez-Madrid F: Induction of tyrosine phosphorylation during ICAM-3 and LFA-1-mediated intercellular adhesion, and its regulation by the CD45 tyrosine phosphatase. J Cell Biol. 1994 Sep;126(5):1277-86. Hernandez-Caselles T, Rubio G, Campanero MR, del Pozo MA, Muro M, Sanchez-Madrid F, Aparicio P: ICAM-3, the third LFA-1 counterreceptor, is a co-stimulatory molecule for both resting and activated T lymphocytes. Eur J Immunol. 1993 Nov;23(11):2799-806. Campanero MR, del Pozo MA, Arroyo AG, SÃ¡nchez-Mateos P, HernÃ¡ndez-Caselles T, Craig A, Pulido R, SÃ¡nchez-Madrid F. ICAM-3 interacts with LFA-1 and regulates the LFA-1/ICAM-1 cell adhesion pathway. J Cell Biol. 1993 Nov;123(4):1007-16.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	CD50;CDW50;ICAM-3;ICAM-R;intercellular adhesion molecule 3.
Similar products	CD50
Shipping Condition	Cool pack
Available
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Applications	Flow cytometry\|Functional assay\|Immunohistochemistry-Paraffin
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	ICAM3
Gene Fullname	intercellular adhesion molecule 3
Product format	Phosphate buffered saline (PBS), pH 7.4
Reconstitution and storage	2°C to 8°C
Description of target	ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Nucleotide accession_num	NM_002162.3
Protein accession_num	NP_002153.2
Protein name	Intercellular adhesion molecule 3
Clonality	Monoclonal
Purification	Purified
Immunogen	Leukocytes of a patient suffering from LGL-type leukemia.
Manufacturer - Specificity	The antibody MEM-04 reacts with CD50 (ICAM-3), a 120-130 kDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells and Langerhans cells; it is negative on platelets and erythrocytes. The MEM-04 blocks DC-SIGN (CD209) binding to ICAM-3 (epitope in D1).
Formulation	Low endotoxin
Concentration	1 mg/ml
Storage Buffer	Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 um filter sterilized. Endotoxin level is less than 0.01 EU/ug of the protein, as determined by the LAL test.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg (C100)

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