MAb to EGFR activated pTyr1173 Antibody (0.1mg)

MAb to EGFR activated pTyr1173 (0.1mg)

MAb to EGFR activated pTyr1173, Monoclonal Antibody to Human Epidermal Growth Factor Receptor (EGFR), phosphorylated at Tyrosine 1173 Biotin conjugated

Epidermal Growth Factor Receptor (EGFR), phospho-Tyr 1173 & Positive Control Binding of EGF to the extracellular domain of the EGF-receptor results in receptor dimerization and tophosphorylation on tyrosine residues, Y1173 being the major autophosphorylation site. Clone 9H2 specifically interacts with the 1170 - NAEpYLRV motif corresponding to the major autophosphorylation site of human EGFR. The antibody does not interact with the non-phosphorylated EGFR nor with unrelated Tyrosine-phosphorylated proteins. This phosphorylation site-specific monoclonal antibody allows the detection and quantification of activated EGFR in crude cell extracts in Immunoblot, ELISA and Biosensor assay formats without the use of P32. Reacts with Human, mouse, and dog.

Thiophilic adsorption and size exclusion chromatography