C7 Antibody

ArtNr	OASA01019
Hersteller	AVIVA Systems Biology
Menge	0.1 mg
Kategorie	Antibodies Western Blot ELISA Primary Antibodies Immunostaining Functional Assays
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, ELISA, FA
Clon	030-113.7.5.4
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1
Citations	1. Thai, C. et al. (2005) Complement components C5 and C7: recombinant factor I modules of C7 bind to the C345C domain of C5. J. Immunol. 174: 6227-32. 2. Debard AL et al. (2005) FcgammaRIIIb and complement component C7 codeficiency in a patient with recurrence of fulminant meningococcal septic shock. Clin. Infect. Dis. 40: 1679-83.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	C7
Similar products	C7
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Polyclonal Antibodies/RNA Binding Proteins, Root Catalog/Research Areas/Immunology, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	C7
Protein size	843
Product format	Liquid. Borate buffered saline
Reconstitution and storage	-20°C
Description of target	MOUSE ANTI HUMAN C7
Protein accession_num	NP_000578.2
Protein name	Complement component C7
Clonality	Monoclonal
Purification	Purified IgG prepared by affinity chromatography on Protein A from ascites
Immunogen	Purified human C7.
Homology	Human
Manufacturer - Specificity	Mouse anti Human C7 antibody, clone 030-113.7.5.4 recognises complement component 7 (C7), a 110 kDa glycoprotein present in the blood serum. The factor I domain of C7 binds the C terminus of the C5 alpha-chain, acting as a membrane anchor. This enables the assembly of the complement membrane attack complex (MAC) and consequent complement lytic activity. C7 deficiency is associated with increased susceptibility to recurrent infections, in particular by Neisseria meningitides. Mouse anti Human C7 antibody, clone 030-113.7.5.4 does not recognize membrane bound complement membrane attack complex. Mouse anti Human C7 antibody, clone 030-113.7.5.4 inhibits lysis of sensitised sheep erythrocytes. Removal of Sodium Azide is recommended prior to use in functional assays. Aviva recommends the use of OOSA11305 for this purpose.
Concentration	1 mg/ml

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Menge: 0.1 mg

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