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SETD2 Antibody - N-terminal region

SETD2 Antibody - N-terminal region

ArtNr	OAAB20013
Hersteller	AVIVA Systems Biology
Menge	400 ul
Kategorie	Oncology Neuroscience Metabolism Cholesterol & Lipid Metabolism Aging & Neurological Disorders Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Melanoma Sarcoma Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	ELISA, IHC-P
Clon	RB2780
Specific against	Mouse (Murine, Mus musculus)
Host	Rabbit
Citations	Rega, S., et al., Mol. Cell. Neurosci. 18(1):68-79 (2001). Passani, L.A., et al., Hum. Mol. Genet. 9(14):2175-2182 (2000). Faber, P.W., et al., Hum. Mol. Genet. 7(9):1463-1474 (1998).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	LLS,HYPB,SET2,HIF-1,HIP-1,KMT3A,HBP231,HSPC069,p231HBP
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Manufacturer - Isotype	Rabbit Ig
Shipping Temperature	Wet Ice
Molecular Weight	288 kDa
Species Tested	Human
Manufacturer - Application Additional Information	IHC-P: 1:50~100
Gene symbol	SETD2
Gene Fullname	SET domain containing 2
Product format	Liquid PBS with 0.09% (w/v) sodium azide
Reconstitution and storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Description of target	SET2 is a histone methyltransferase that methylates 'Lys-36' of histone H3. H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. This protein probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. SET2 binds DNA at promoters, and may act as a transcription activator. SET2 binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. SET2 belongs to a class of huntingtin interacting proteins characterized by WW motifs.
Nucleotide accession_num	NM_014159.6
Protein accession_num	NP_054878.5
Clonality	Polyclonal
Purification	This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogen	This SET2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21~50 amino acids from the N-terminal region of human SET2.
Homology	Human
Formulation	Purified polyclonal antibody, supplied in PBS with 0.09% sodium azide.
Concentration	1.7 mg/mL

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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OAAB20013-datasheet.pdf

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