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SETD2 Antibody - N-terminal region

SETD2 Antibody - N-terminal region

Item no.	OAAB20013
Manufacturer	AVIVA Systems Biology
Amount	400 ul
Category	Oncology Neuroscience Metabolism Cholesterol & Lipid Metabolism Aging & Neurological Disorders Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Melanoma Sarcoma Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	ELISA, IHC-P
Clone	RB2780
Specific against	Mouse (Murine, Mus musculus)
Host	Rabbit
Citations	Rega, S., et al., Mol. Cell. Neurosci. 18(1):68-79 (2001). Passani, L.A., et al., Hum. Mol. Genet. 9(14):2175-2182 (2000). Faber, P.W., et al., Hum. Mol. Genet. 7(9):1463-1474 (1998).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	LLS,HYPB,SET2,HIF-1,HIP-1,KMT3A,HBP231,HSPC069,p231HBP
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Manufacturer - Isotype	Rabbit Ig
Shipping Temperature	Wet Ice
Molecular Weight	288 kDa
Species Tested	Human
Manufacturer - Application Additional Information	IHC-P: 1:50~100
Gene symbol	SETD2
Gene Fullname	SET domain containing 2
Product format	Liquid PBS with 0.09% (w/v) sodium azide
Reconstitution and storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Description of target	SET2 is a histone methyltransferase that methylates 'Lys-36' of histone H3. H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. This protein probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. SET2 binds DNA at promoters, and may act as a transcription activator. SET2 binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. SET2 belongs to a class of huntingtin interacting proteins characterized by WW motifs.
Nucleotide accession_num	NM_014159.6
Protein accession_num	NP_054878.5
Clonality	Polyclonal
Purification	This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogen	This SET2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21~50 amino acids from the N-terminal region of human SET2.
Homology	Human
Formulation	Purified polyclonal antibody, supplied in PBS with 0.09% sodium azide.
Concentration	1.7 mg/mL

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 1/8/2026

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