ACKR1 Antibody

ArtNr	OACA04814
Hersteller	AVIVA Systems Biology
Menge	50 ug
Kategorie	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Neural Signaling Antibodies By Cell Type Carcinoma Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart Studies." Nalls M.A., Wilson J.G., Patterson N.J., Tandon A., Zmuda J.M., Huntsman S., Garcia M., Hu D., Li R., Beamer B.A., Patel K.V., Akylbekova E.L., Files J.C., Hardy C.L., Buxbaum S.G., Taylor H.A., Reich D., Harris T.B., Ziv E.Am. J. Hum. Genet. 82:81-87(2008). [2]"A novel mutation in the coding sequence of the FY*B allele of the Duffy chemokine receptor gene is associated with an altered erythrocyte phenotype." Parasol N., Reid M., Rios M., Castilho L., Harari I., Kosower N.S.Blood 92:2237-2243(1998). [3]"Molecular basis and PCR-DNA typing of the Fya/fyb blood group polymorphism." Tournamille C., Le van Kim C., Gane P., Cartron J.-P., Colin Y. Hum. Genet. 95:407-410(1995).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	atypical chemokine receptor 1;CCBP1;CD234;DARC;DARC/ACKR1;Dfy;Duffy antigen chemokine receptor;Duffy antigen/chemokine receptor;Duffy blood group antigen;Duffy blood group system protein;Duffy blood group,chemokine receptor;FY;Fy glycoprotein;glycoprotein D;GPD;GpFy;plasmodium vivax receptor;WBCQ1.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	ACKR1
Gene Fullname	atypical chemokine receptor 1 (Duffy blood group)
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
Nucleotide accession_num	NM_001122951
Protein accession_num	NP_001116423
Protein name	Atypical chemokine receptor 1
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human Atypical chemokine receptor 1 protein (1-63AA)
Formulation	50% Glycerol, 0.01M PBS, PH 7.4

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Menge: 50 ug

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