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ACKR1 Antibody

ACKR1 Antibody

Item no.	OACA04814
Manufacturer	AVIVA Systems Biology
Amount	50 ug
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Neural Signaling Antibodies By Cell Type Carcinoma Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IF, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]"Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart Studies." Nalls M.A., Wilson J.G., Patterson N.J., Tandon A., Zmuda J.M., Huntsman S., Garcia M., Hu D., Li R., Beamer B.A., Patel K.V., Akylbekova E.L., Files J.C., Hardy C.L., Buxbaum S.G., Taylor H.A., Reich D., Harris T.B., Ziv E.Am. J. Hum. Genet. 82:81-87(2008). [2]"A novel mutation in the coding sequence of the FY*B allele of the Duffy chemokine receptor gene is associated with an altered erythrocyte phenotype." Parasol N., Reid M., Rios M., Castilho L., Harari I., Kosower N.S.Blood 92:2237-2243(1998). [3]"Molecular basis and PCR-DNA typing of the Fya/fyb blood group polymorphism." Tournamille C., Le van Kim C., Gane P., Cartron J.-P., Colin Y. Hum. Genet. 95:407-410(1995).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	atypical chemokine receptor 1;CCBP1;CD234;DARC;DARC/ACKR1;Dfy;Duffy antigen chemokine receptor;Duffy antigen/chemokine receptor;Duffy blood group antigen;Duffy blood group system protein;Duffy blood group,chemokine receptor;FY;Fy glycoprotein;glycoprotein D;GPD;GpFy;plasmodium vivax receptor;WBCQ1.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	ACKR1
Gene Fullname	atypical chemokine receptor 1 (Duffy blood group)
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
Nucleotide accession_num	NM_001122951
Protein accession_num	NP_001116423
Protein name	Atypical chemokine receptor 1
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human Atypical chemokine receptor 1 protein (1-63AA)
Formulation	50% Glycerol, 0.01M PBS, PH 7.4

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 12/25/2025

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