CASP14 Antibody

ArtNr	OACA06824
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Neuroinflammation Antibodies By Cell Type Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation." Chien A.J., Presland R.B., Kuechle M.K. Biochem. Biophys. Res. Commun. 296:911-917(2002). [2]Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing." Lippens S., Kockx M., Knaapen M., Mortier L., Polakowska R., Verheyen A., Garmyn M., Zwijsen A., Formstecher P., Huylebroeck D., Vandenabeele P., Declercq W. Cell Death Differ. 7:1218-1224(2000). [3]Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E., Vandekerckhove J.Electrophoresis 13:960-969(1992).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	apoptosis-related cysteine protease;ARCI12;CASP-14;caspase 14,apoptosis-related cysteine peptidase;caspase 14,apoptosis-related cysteine protease;caspase-14.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	CASP14
Gene Fullname	caspase 14
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736).
Nucleotide accession_num	NM_012114
Protein accession_num	NP_036246
Protein name	Caspase-14
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Caspase-14 protein (1-242AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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