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CASP14 Antibody

CASP14 Antibody

Item no.	OACA06824
Manufacturer	AVIVA Systems Biology
Amount	50 ul
Category	Oncology Neuroscience Neuroinflammation Antibodies By Cell Type Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation." Chien A.J., Presland R.B., Kuechle M.K. Biochem. Biophys. Res. Commun. 296:911-917(2002). [2]Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing." Lippens S., Kockx M., Knaapen M., Mortier L., Polakowska R., Verheyen A., Garmyn M., Zwijsen A., Formstecher P., Huylebroeck D., Vandenabeele P., Declercq W. Cell Death Differ. 7:1218-1224(2000). [3]Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E., Vandekerckhove J.Electrophoresis 13:960-969(1992).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	apoptosis-related cysteine protease;ARCI12;CASP-14;caspase 14,apoptosis-related cysteine peptidase;caspase 14,apoptosis-related cysteine protease;caspase-14.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	CASP14
Gene Fullname	caspase 14
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736).
Nucleotide accession_num	NM_012114
Protein accession_num	NP_036246
Protein name	Caspase-14
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Caspase-14 protein (1-242AA)
Formulation	PBS with, 50% glycerol, pH7.3.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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