GZMA Antibody

ArtNr	OACA06883
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Neuroscience Molecular Targets for Neuroscience Antibodies Immunohistochemistry ELISA Immunofluorescence Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"Crystal structure of the apoptosis-inducing human granzyme A dimer."Hink-Schauer C., Estebanez-Perpina E., Kurschus F.C., Bode W., Jenne D.E.Nat. Struct. Biol. 10:535-540(2003). [2]"The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity." Bell J.K., Goetz D.H., Mahrus S., Harris J.L., Fletterick R.J., Craik C.S.Nat. Struct. Biol. 10:527-534(2003). [3]"Comparative molecular model building of two serine proteinases from cytotoxic T lymphocytes." Murphy M.E.P., Moult J., Bleackley R.C., Gershenfeld H., Weissman I.L., James M.N.G. Proteins 4:190-204(1988).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CTL tryptase;CTLA3;cytotoxic T-lymphocyte proteinase 1;Cytotoxic T-lymphocyte-associated serine esterase-3;fragmentin-1;granzyme 1;granzyme A;Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine protease);granzyme A (granzyme 1,cytotoxic T-lymphocyte-associated serine esterase 3);Granzyme-1;h factor;Hanukah factor serine protease);Hanukkah factor;HF;HFSP.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	GZMA
Gene Fullname	granzyme A
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.
Nucleotide accession_num	NM_006144
Protein accession_num	NP_006135
Protein name	Granzyme A
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Granzyme A protein (29-262AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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