LRP6 Antibody

ArtNr	OACA06970
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Neural Mitochondrial Function Molecular Targets for Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Antibodies By Cell Type Carcinoma Cell Biology Obesity Cell Status Apoptosis Immunohistochemistry ELISA Lipoprotein Receptors & Associated Proteins Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."The MGC Project Team Genome Res. 14:2121-2127(2004). [2]"Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6." Semenov M.V., Tamai K., Brott B.K., Kuhl M., Sokol S., He X.Curr. Biol. 11:951-961(2001) . [3]"LDL-receptor-related protein 6 is a receptor for Dickkopf proteins." Mao B., Wu W., Li Y., Hoppe D., Stannek P., Glinka A., Niehrs C.Nature 411:321-325(2001)
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ADCAD2;low-density lipoprotein receptor-related protein 6;LRP-6;STHAG7.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	LRP6
Gene Fullname	LDL receptor related protein 6
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
Nucleotide accession_num	NM_002336
Protein accession_num	NP_002327
Protein name	Low-density lipoprotein receptor-related protein 6
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Low-density lipoprotein receptor-related protein 6 protein (20-150AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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