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LRP6 Antibody

LRP6 Antibody

Item no.	OACA06970
Manufacturer	AVIVA Systems Biology
Amount	50 ul
Category	Oncology Neuroscience Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Neural Mitochondrial Function Molecular Targets for Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Antibodies By Cell Type Carcinoma Cell Biology Obesity Cell Status Apoptosis Immunohistochemistry ELISA Lipoprotein Receptors & Associated Proteins Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."The MGC Project Team Genome Res. 14:2121-2127(2004). [2]"Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6." Semenov M.V., Tamai K., Brott B.K., Kuhl M., Sokol S., He X.Curr. Biol. 11:951-961(2001) . [3]"LDL-receptor-related protein 6 is a receptor for Dickkopf proteins." Mao B., Wu W., Li Y., Hoppe D., Stannek P., Glinka A., Niehrs C.Nature 411:321-325(2001)
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ADCAD2;low-density lipoprotein receptor-related protein 6;LRP-6;STHAG7.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	LRP6
Gene Fullname	LDL receptor related protein 6
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
Nucleotide accession_num	NM_002336
Protein accession_num	NP_002327
Protein name	Low-density lipoprotein receptor-related protein 6
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Low-density lipoprotein receptor-related protein 6 protein (20-150AA)
Formulation	PBS with, 50% glycerol, pH7.3.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ul

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Delivery expected until 12/25/2025

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