GRK6 Antibody

ArtNr	OACA07205
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Obesity Immunohistochemistry Western Blot ELISA Lipoprotein Receptors & Associated Proteins Cardiovascular Research Atherosclerosis Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"Patterns of somatic mutation in human cancer genomes."Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. Stratton M.R. Nature 446:153-158(2007). [2]"Molecular basis for activation of G protein-coupled receptor kinases."Boguth C.A., Singh P., Huang C.C., Tesmer J.J.EMBO J. 29:3249-3259(2010). [3]"The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs."Lodowski D.T., Tesmer V.M., Benovic J.L., Tesmer J.J.J. Biol. Chem. 281:16785-16793(2006).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	G protein-coupled receptor kinase 6;G protein-coupled receptor kinase GRK6;GPRK6.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	GRK6
Gene Fullname	G protein-coupled receptor kinase 6
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
Nucleotide accession_num	NM_001004105
Protein accession_num	NP_001004105
Protein name	G protein-coupled receptor kinase 6
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human G protein-coupled receptor kinase 6 protein (1-170AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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