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GRK6 Antibody

GRK6 Antibody

Item no.	OACA07205
Manufacturer	AVIVA Systems Biology
Amount	50 ul
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Obesity Immunohistochemistry Western Blot ELISA Lipoprotein Receptors & Associated Proteins Cardiovascular Research Atherosclerosis Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	[1]"Patterns of somatic mutation in human cancer genomes."Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. Stratton M.R. Nature 446:153-158(2007). [2]"Molecular basis for activation of G protein-coupled receptor kinases."Boguth C.A., Singh P., Huang C.C., Tesmer J.J.EMBO J. 29:3249-3259(2010). [3]"The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs."Lodowski D.T., Tesmer V.M., Benovic J.L., Tesmer J.J.J. Biol. Chem. 281:16785-16793(2006).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	G protein-coupled receptor kinase 6;G protein-coupled receptor kinase GRK6;GPRK6.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	GRK6
Gene Fullname	G protein-coupled receptor kinase 6
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
Nucleotide accession_num	NM_001004105
Protein accession_num	NP_001004105
Protein name	G protein-coupled receptor kinase 6
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human G protein-coupled receptor kinase 6 protein (1-170AA)
Formulation	PBS with, 50% glycerol, pH7.3.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ul

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Delivery expected until 12/25/2025

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