TDP1 Antibody

ArtNr	OACA07256
Hersteller	AVIVA Systems Biology
Menge	50 ul
Kategorie	Antibodies Immunohistochemistry Immunoprecipitation Western Blot ELISA Cardiovascular Research Thrombosis & Hemostasis Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IP, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?"Hirano R., Interthal H., Huang C., Nakamura T., Deguchi K., Choi K., Bhattacharjee M.B., Arimura K., Umehara F., Izumo S., Northrop J.L., Salih M.A.M., Inoue K., Armstrong D.L., Champoux J.J., Takashima H., Boerkoel C.F. EMBO J. 26:4732-4743(2007). [2]"SCAN1 mutant Tdp1 accumulates the enzyme-DNA intermediate and causes camptothecin hypersensitivity."Interthal H., Chen H.J., Kehl-Fie T.E., Zotzmann J., Leppard J.B., Champoux J.J.EMBO J. 24:2224-2233(2005).
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	tyr-DNA phosphodiesterase 1;tyrosyl-DNA phosphodiesterase 1.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	TDP1
Gene Fullname	tyrosyl-DNA phosphodiesterase 1
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.
Nucleotide accession_num	NM_001008744
Protein accession_num	NP_001008744
Protein name	Tyrosyl-DNA phosphodiesterase 1
Clonality	Polyclonal
Purification	Affinity Purified
Immunogen	Recombinant Human Tyrosyl-DNA phosphodiesterase 1 protein (1-260AA)
Formulation	PBS with, 50% glycerol, pH7.3.

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