NUPR1 Antibody

ArtNr	OACA10530
Hersteller	AVIVA Systems Biology
Menge	50 ug
Kategorie	Oncology Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Cell Biology Cell Status Apoptosis Adenocarcinoma Mesothelioma Immunohistochemistry ELISA Immunofluorescence Autophagy Senescence Cardiovascular Research Proliferation Myocardial Infarction Primary Antibodies By Organ Lung Cancer Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	IF, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Purity	>95%
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	candidate of metastasis 1;COM1;nuclear protein 1;nuclear protein,transcriptional regulator,1;nuclear transcriptional regulator protein 1;P8;protein p8.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	IF: 1:50~200IHC: 1:20~200
Gene symbol	NUPR1
Gene Fullname	nuclear protein 1, transcriptional regulator
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 'Lys-16' acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin.
Nucleotide accession_num	NM_001042483
Protein accession_num	NP_001035948
Protein name	Nuclear protein 1
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human Nuclear protein 1 protein (2-64AA)
Formulation	50% Glycerol, 0.01M PBS, pH 7.4
Concentration	Varies by lot. See vial for concentration.

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Menge: 50 ug

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Lieferung vsl. bis 30.10.2025

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