MIB1 Antibody

ArtNr	OACD05574
Hersteller	AVIVA Systems Biology
Menge	100 ul
Kategorie	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Antibodies By Cell Type Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis Immunohistochemistry Immunoprecipitation Western Blot Immunocytochemistry Primary Antibodies By Organ Heart & Blood Cancer Immunochemistry
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IP, IHC, ICC
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	DAPK-interacting protein 1;DIP1;DIP-1;E3 ubiquitin-protein ligase MIB1;LVNC7;MIB;Mind bomb homolog 1;mindbomb E3 ubiquitin protein ligase 1;RING-type E3 ubiquitin transferase MIB1;ubiquitin ligase mind bomb;zinc finger ZZ type with ankyrin repeat domain protein 2;ZZANK2;ZZZ6.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Molecular Weight	110 kDa
Application Data	Western blotting: 1:50-400 Immunocytochemistry in formalin fixed cells: 1:50-500 Immunohistochemistry in formalin fixed frozen section: 1:50-500 Immunohistochemistry in paraffin section: 1:10-100 Enzyme-linked Immunosorbent Assay: 1:100-1:5, 000 Optimal working dilutions must be determined by end user.
Gene symbol	MIB1
Gene Fullname	MIB E3 ubiquitin protein ligase 1
Product format	Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution and storage	2°C to 8°C\|-20°C
Description of target	E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.
Nucleotide accession_num	NM_020774
Protein accession_num	NP_065825.1
Protein name	E3 ubiquitin-protein ligase MIB1
Clonality	Polyclonal
Purification	Affinity Purified; Protein A Purified
Immunogen	Range: Arg769 - Glu1000
Manufacturer - Specificity	The antibody is a rabbit polyclonal antibody raised against MIB1. It has been selected for its ability to recognize MIB1 in immunohistochemical staining and western blotting.
Formulation	PBS, pH7.4, containing 0.02% NaN3, 50% glycerol
Concentration	0.5 mg/ml

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OACD05574-datasheet.pdf

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Menge: 100 ul

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Lieferung vsl. bis 30.10.2025

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