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IL4R Antibody (Phospho-Tyr497)

IL4R Antibody (Phospho-Tyr497)

ArtNr	OASG03842
Hersteller	AVIVA Systems Biology
Menge	100 ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite Molecular Targets for Neuroscience Neural Signaling Neural Adhesion Molecules Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Melanoma Cell Biology Cell Culture Cytokines Immunohistochemistry Western Blot Immunofluorescence Endocrine Regulation of Lipid Metabolism Primary Antibodies Neuronal Cell Markers
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CD124,IL4RA,IL-4RA
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Polyclonal Antibodies/Phospho Specific, Root Catalog/Products/Primary Antibodies
Manufacturer - Targets	On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction. The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.
Shipping Temperature	Wet Ice
Storage Conditions	IL4R
Molecular Weight	90 kDa
Manufacturer - Application Additional Information	WB: 1:500-1:2000IHC: 1:100-1:300IF: 1:200-1:1000ELISA: 1:5000Optimal dilutions should be determined by the end user.
Gene symbol	IL4R
Gene Fullname	interleukin 4 receptor
Product format	Liquid.PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Reconstitution and storage	Store at -20C, and avoid repeat freeze-thaw cycles.
Description of target	Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.
Clonality	Polyclonal
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen	Synthesized peptide derived between 440-520 aa from human IL-4Ralpha around the phosphorylation site of Y497.
Manufacturer - Specificity	Phospho-IL-4Ralpha (Y497) Polyclonal Antibody detects endogenous levels of IL-4Ralpha protein only when phosphorylated at Y497.
Concentration	1 mg/ml

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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OASG03842-datasheet.pdf

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Menge: 100 ul

lieferbar

Lieferung vsl. bis 08.01.2026